Year
2023
Authors
PUYOU DE POUVOURVILLE Gérard, AKEHURST Ron, MURPHY Linda A., SOLÀ-MORALES Oriol, CUNNINGHAM David, MESTRE-FERRANDIZ Jorge
Abstract
In the past decade, there have been increasing calls for greater use of real-world evidence (RWE) and data (RWD), with the explicit goal of enabling faster provision of effective medicines to patients in need. The push for decision makers to accept RWE is especially noticeable in the pursuit of regulatory approval, but RWE, particularly when used to estimate the relative effectiveness of interventions, is not always readily accepted by agencies responsible for reimbursement and pricing of new pharmaceuticals and, to a varying degree, is not accepted across jurisdictions. This lack of trust hampers the use of RWE despite a very large and growing literature base on the principles of how RWE should be used.
AKEHURST, R., MURPHY, L.A., SOLÀ-MORALES, O., CUNNINGHAM, D., MESTRE-FERRANDIZ, J. et PUYOU DE POUVOURVILLE, G. (2023). Using Real-World Data in the Health Technology Assessment of Pharmaceuticals: Strengths, Difficulties, and a Pragmatic Way Forward. Value in Health, 26(4), pp. 11-19.