Year
2024
Authors
PUYOU DE POUVOURVILLE Gérard, Viguier Manuelle, Bentayeb Malek, Azzi Jessica, Gloede Tristan, Langellier Bérengère, Massol Jacques, Medina Patricia, Thoma Christian, Bachelez Hervé
Abstract
GPP is a rare, chronic, neutrophilic skin disease, with limited real-world data characterizing patients with flares and the impact of flares on disease progression and morbidity. Objective: Describe the clinical characteristics of patients with GPP, comorbidities, disease epidemiology and frequency and severity of flares, and compare patients with GPP with a matched severe psoriasis population. Methods: In this population-based real-world cohort study an algorithm was developed to identify patients with GPP flares. Three cohorts were identified using the Système National des Données de Santé (SNDS) database covering almost the entire French population; a prevalent cohort (2010–2018), an incident cohort (2012–2015). A severe psoriasis cohort was compared with the GPP incident cohort using propensity score matching. Patients with GPP had a distinct comorbidity profile compared to patients with severe psoriasis, and GPP flares were associated with long hospitalizations.
VIGUIER, M., BENTAYEB, M., AZZI, J., PUYOU DE POUVOURVILLE, G., GLOEDE, T., LANGELLIER, B. … BACHELEZ, H. (2024). Generalized pustular psoriasis: A nationwide population‐based study using the National Health Data System in France. Journal of the European Academy of Dermatology and Venereology, 38(6), pp. 1131-1139.