The Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS) randomized clinical trial demonstrated the efficacy of eplerenone, a new aldosterone antagonist diuretic, with standard treatment versus standard treatment alone in the reduction of cardiovascular mortality and cardiovascular-related hospital readmissions for patients with heart failure after an acute myocardial infarction.We assessed the incremental cost per life-year saved of eplerenone in the French context versus standard treatment.
PUYOU DE POUVOURVILLE, G., SOLESSE, A. and BEILLAT, M. (2008). Cost-effectiveness Analysis of Aldosterone Blockade with Eplerenone in Patients with Heart Failure after Acute Myocardial Infarction in the French Context: The EPHESUS Study. Archives of Cardiovascular Diseases, 101(9), pp. 515-521.