The authors' objective was to assess the bidirectional relationship between adherence and response to treatment among patients enrolled in the ANRS CO8 APROCO-COPILOTE study. We compared a conventional statistical approach based on the separate estimations of an adherence and an effectiveness equation to an econometric approach using a 2-equation simultaneous system based on the same 2 equations. The authors' results, which suggest that positive biological results arising as a result of high adherence levels, in turn reinforce continued adherence and strengthen the argument that patients who do not experience rapid improvement in their immunologic and clinical statuses after HAART initiation should be prioritized when developing adherence support interventions. Furthermore, they invalidate the hypothesis that HAART leads to “false reassurance” among HIV-infected patients.
LAMIRAUD, K., MOATTI, J.P., RAFFI, F., CARRIERI, M.P., PROTOPOPESCU, C. and MICHELET, C. (2012). Adherence to and Effectiveness of Highly Active Antiretroviral Treatment for HIV Infection. Medical Care, 50(5), pp. 410-418.