Osteoporosis is a common disorder of the skeleton that increases bone fragility and the risk of fracture. Bisphosphonates have become the reference treatment for postmenopausal osteoporosis because of their proven efficacy in reducing fracture rates. The effectiveness of bisphosphonates is, however, limited by poor treatment adherence and persistence with treatment. A model has been designed to simulate the impact of improving persistence rates on treatment effectiveness.
COTTE, F.E., FAUTREL, B. and PUYOU DE POUVOURVILLE, G. (2009). A Markov Model Simulation of the Impact of Treatment Persistence in Postmenopausal Osteoporosis. Medical Decision Making, 29(1), pp. 125-139.